What should you pay attention to when taking Sutent?
Sutent (sunitinib) is a targeted anti-tumor drug commonly used to treat malignant tumors such as renal cell carcinoma and gastrointestinal stromal tumors. Correct dosing of Sutent is critical to efficacy and safety. The following are the precautions for taking Sutent, compiled based on the hot medical topics on the Internet in the past 10 days.
1. Basic information about Sutan
| common name | Trade name | Indications | Common specifications |
|---|---|---|---|
| sunitinib | Sutent | Renal cell carcinoma, gastrointestinal stromal tumor, etc. | 12.5mg, 25mg, 50mg capsules |
2. How to take and dosage
1.Standard dosage:Usually 50mg/day, take it continuously for 4 weeks and then stop taking it for 2 weeks (4/2 plan). Specific adjustments need to be made according to the doctor's advice.
2.Medication time:It is recommended to take it at a fixed time (such as after breakfast) to avoid missing doses.
3.Treatment of missed doses:If you miss a dose within 12 hours, you can make up for it; if it exceeds 12 hours, skip it and take it normally the next day.
| Applicable people | Dosage adjustment recommendations |
|---|---|
| People with liver insufficiency | The dose needs to be reduced by 25%-50% |
| Grade 3 or above adverse reactions occur | Suspension of medication until recovery and subsequent dose reduction |
3. Common adverse reactions and treatments
| adverse reactions | incidence | Countermeasures |
|---|---|---|
| fatigue | ≥70% | Arrange your rest appropriately and avoid strenuous exercise |
| Diarrhea | 40%-60% | Replenish electrolytes and use antidiarrheal medicine if necessary |
| high blood pressure | 15%-30% | Regular monitoring, combined with antihypertensive treatment |
4. Drug interaction taboos
1.Strong inhibitors of CYP3A4:For example, ketoconazole and clarithromycin may increase the blood concentration of Sutent, so combined use should be avoided.
2.CYP3A4 inducers:For example, rifampicin and phenytoin may reduce the efficacy and the dose needs to be adjusted.
3.Other anticoagulant drugs:Increased risk of bleeding and requires close monitoring.
5. Suggestions on diet and living habits
1.Diet:Avoid grapefruit and its products (which affect drug metabolism), and a high-protein diet can reduce gastrointestinal reactions.
2.Sun protection:Sutent may cause photosensitivity reactions, so you need to use sunscreen with SPF ≥ 30 when going out.
3.Vaccination:Avoid live vaccines while taking this medication.
6. Precautions for special groups of people
| crowd | Things to note |
|---|---|
| pregnant woman | Disabled, may cause fetal malformation |
| lactating women | Stop taking medication or breastfeeding |
| elderly | Closely monitor cardiovascular function |
7. Answers to recent hot questions
1.Q: Can Sutent be used in combination with traditional Chinese medicine?
A: Some Chinese medicines (such as St. John's wort) may interfere with the efficacy of the medicine, so you need to consult a doctor.
2.Q: What should I do if my hands and feet hurt after taking medicine?
A: It may be hand-foot syndrome, which can be relieved with urea ointment. In severe cases, the dosage needs to be reduced.
3.Q: How to judge whether the medicine is effective?
A: Tumor changes need to be evaluated through regular imaging examinations (such as CT).
Summary:Standard use of Sutent requires strict compliance with medical instructions and regular review of blood routine, liver and kidney function and other indicators. If serious adverse reactions or poor efficacy occur, you should promptly communicate with the attending doctor to adjust the treatment plan.
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