What is meropenem
Meropenem is a broad-spectrum antibiotic that belongs to the carbapenem class of antibiotics. It exerts a powerful bactericidal effect by inhibiting bacterial cell wall synthesis. Meropenem is effective against a variety of Gram-positive and Gram-negative bacteria, and plays an important role in the treatment of severe infections and drug-resistant bacterial infections. The following is a detailed analysis of meropenem.
1. Basic information about meropenem
The chemical name of Meropenem is (4R,5S,6S)-3-[[(3S,5S)-5-(dimethylcarbamoyl)-3-pyrrolidinyl]sulfide]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid trihydrate. Its molecular formula is C17H25N3O5S·3H2O, molecular weight is 437.51.
| Project | content |
|---|---|
| common name | Meropenem |
| English name | Meropenem |
| drug class | carbapenem antibiotics |
| Indications | Severe infections, drug-resistant bacterial infections, abdominal infections, pneumonia, etc. |
| Dosage form | Injections |
2. Pharmacological effects of meropenem
Meropenem causes bacterial lysis and death by inhibiting bacterial cell wall synthesis. It is stable to a variety of β-lactamases, so it also has a good effect on drug-resistant bacteria. The following is the antibacterial spectrum of meropenem:
| Bacteria type | Examples of sensitive bacteria |
|---|---|
| Gram-positive bacteria | Staphylococcus aureus, Streptococcus pneumoniae |
| Gram-negative bacteria | Escherichia coli, Pseudomonas aeruginosa |
| Anaerobic bacteria | Bacteroides fragilis |
3. Clinical application of meropenem
Meropenem is mainly used to treat the following infections:
| Type of infection | specific disease |
|---|---|
| abdominal infection | peritonitis, abdominal abscess |
| respiratory tract infection | pneumonia, bronchitis |
| urinary tract infection | Pyelonephritis |
| Skin and soft tissue infections | Cellulitis |
4. Precautions for use of meropenem
1.allergic reaction: Contraindicated for those allergic to carbapenem antibiotics.
2.Kidney function adjustment: Patients with renal insufficiency require dose adjustment.
3.drug resistance: Long-term use may lead to the development of drug-resistant bacteria.
4.adverse reactions: Common adverse reactions include diarrhea, nausea, rash, etc.
5. The relationship between hot topics in the past 10 days and meropenem
Recently, there has been a surge in cases of drug-resistant bacterial infections in many places around the world. As an important drug for the treatment of drug-resistant bacterial infections, meropenem has once again become a hot topic in the medical field. The following is the hot content related to meropenem in the past 10 days:
| Date | Hot content |
|---|---|
| 2023-11-01 | A hospital reported that meropenem successfully treated cases of multidrug-resistant bacterial infections |
| 2023-11-03 | WHO calls for rational use of carbapenem antibiotics |
| 2023-11-05 | Study finds combined use of meropenem improves efficacy |
| 2023-11-08 | The supply of meropenem in a certain region is tight, causing concern |
6. Summary
Meropenem is a highly effective, broad-spectrum antibiotic that plays an irreplaceable role in the treatment of severe infections and drug-resistant bacterial infections. However, its use must strictly follow medical advice to avoid abuse that may lead to increased drug resistance. With the advancement of medical technology, the clinical application and research of meropenem will continue to contribute to human health.
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